Beta-carboline alkaloids derived from the ascidian Synoicum sp

Bioorg Med Chem. 2012 Jul 1;20(13):4082-7. doi: 10.1016/j.bmc.2012.05.002. Epub 2012 May 11.

Abstract

Six β-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y(1) (7) and six new derivatives, designated eudistomins Y(8)-Y(13) (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na(+)/K(+)-ATPase. Structure-activity relationships were also deduced.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / pharmacology
  • Alkaloids / toxicity
  • Aminoacyltransferases / antagonists & inhibitors
  • Aminoacyltransferases / metabolism
  • Animals
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / pharmacology
  • Anti-Infective Agents / toxicity
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / metabolism
  • Carbolines / chemical synthesis
  • Carbolines / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cysteine Endopeptidases / metabolism
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Humans
  • Isocitrate Lyase / antagonists & inhibitors
  • Isocitrate Lyase / metabolism
  • Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
  • Sodium-Potassium-Exchanging ATPase / metabolism
  • Structure-Activity Relationship
  • Urochordata / chemistry*

Substances

  • Alkaloids
  • Anti-Infective Agents
  • Bacterial Proteins
  • Carbolines
  • Aminoacyltransferases
  • sortase A
  • Cysteine Endopeptidases
  • Isocitrate Lyase
  • Sodium-Potassium-Exchanging ATPase